Sentence examples for specified progenitors from inspiring English sources

Other techniques that are being developed based on the theory of reprogramming and fate change, such as direct lineage conversion or reprogramming of somatic cells into lineage specified progenitors, might fulfill the promises of personalized cell-based therapy.

Once established, this circuit is self-maintained, providing the newly specified progenitors with a memory of their stemness in a similar fashion as OCT4, SOX2, and NANOG in pluripotent ESCs (Boyer et al., 2005).

Significant progress in recent years has identified critical transcription factors which specify progenitors to the cortical projection neuron fate.

Canonical Wnt and its antagonists progressively specify progenitors into surface or neural fates upon neural tube closure.

Our results demonstrate that in planaria, RuvB is required for stem cell function, but it may also play a role in properly specifying progenitors during regeneration.

Thus, the expression of both neuropeptides and their receptors is consistent with a role in initiating Pax6 expression and in specifying progenitors for the olfactory epithelium and the crystalline lens.

At this higher level of organization, common bilaterian strategies for specifying progenitor fields, locking down regulatory states, and driving development forward emerge.

In diverse organisms, co-expression of these 'germline genes' specifies progenitor cells that can contribute to both soma and germline (Juliano et al., 2010).

Numb inheritance specifies progenitor over differentiated cell fates, and, paradoxically, also promotes neuronal differentiation, thus indicating that the role of Numb may change during development.

The basic science of developmental neurobiology explores the elementary processes by which the brain forms (morphogenesis), structure is established (histogenesis), neuronal and glial subtypes are specified from progenitors, connections are established and operates.

In the mouse embryo, the initial population of specified neuroepithelial progenitors (NPs) is known to express various pan-neural genes, like sox1 and sox2 [5], [5].