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Expected survival estimates for 80, 90, or 95% completeness of ascertainment of the specified patient groups were derived by weighted survival analyses, where a weight of 0.8, 0.9, or 0.95, respectively, was assigned to patients in these groups, and a weight of 1 was assigned to all other patients using a recently described SAS macro (Brenner et al, 2004a).
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Finally, we conducted analyses of the full study population, using conditional logistic regression and interaction terms for ER status and tamoxifen therapy to obtain relative risk estimates for the different pre-specified patient groups characterized by these factors.
Whilst the great majority of tools specified the patient group to which the outcome probabilities applied, they did not compare outcomes with and without thrombolysis, did not use identical denominators and time horizons, and failed to adhere to other good practice guidance on presentation of outcome probabilities.
dAuthors did not specify patients in each group.
This review form will be adapted from the Dutch Adverse Event Study [ 34, 39] and adjusted and specified for this patient group.
As specified, results were generated for patient groups, based on ER status and tamoxifen treatment.
NICE guidance specifies entitlement in terms of patient groups and PCTs are obliged to provide funding only for these patients.
In addition, we wanted management to decide upon the best patient mix directly, rather than specifying the weights for all patient groups and therefore indirectly optimizing the patient mix.
As part of the Simon (1989) two-stage minimax design, it was necessary to specify, for each of the patient groups, a 'desired overall response rate' (R1) as well as a 'no further interest response rate' (R0).
These two patient groups are accounted separately and therefore specified in all reports.
We specified relevant treatments for each of the nine mutually exclusive patient groups.
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