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First, they are usually not part of any of the languages themselves but rather stand outside, which means that they are not checked at design time for correctness, but will fail at runtime if specified incorrectly if not for additional tool support.
However, if these were specified incorrectly, the answer was considered wrong.
Another advantage is that even though the correlation model among the related outcome measures may be specified incorrectly, the association model between the outcome and covariates can still obtain a robust result.
If the directionality of R5 or R8 is specified incorrectly, then alerting the user that D is a dead-end metabolite will help the user correct the directionality of R5 or R8, if appropriate.
Several reasons may cause this issue, including ri directly connecting to a dead-end metabolite or to another zero-flux reaction, or if the reversibility of the reaction is specified incorrectly.
Though the sandwich standard error estimator is consistent even when the underlying model is specified incorrectly, it tends to underestimate the standard error of the regression coefficient when the number of clusters is not large enough [ 21, 22].
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Another example is specifying incorrectly the coefficients of a particular reaction.
In terms of evolutionary inference, some of the first molecular phylogenies from ribosomal gene sequences specified, probably incorrectly, that two clades of terrestrial Zygomycota evolved convergently from flagellated, aquatic ancestors.
Sample sizes required for a power of 80% increase from ∼800 subjects in the correctly specified models to over 6,000 or even 16,000 subjects in incorrectly specified models.
The allocations are robust against incorrectly specified regression responses, and against possible heteroscedasticity.
If these components are incorrectly specified, applying such count models could lead to incorrect hotspots.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com