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Changes in initial antibiotic therapy were based on the results of the diagnostic measures specified in the protocol in only 15% of the cases.
If CO2 is specified in the protocol for anesthesia and/or euthanasia, ensuring enough quantity to use for all groups at necropsy is a very important factor.
Clinical trials have traditionally followed a fixed design, in which randomization probabilities of patients to various treatments remains fixed throughout the trial and specified in the protocol.
It is not specified in the protocol when to send the command QueryAdjust.
Some clinical information not specified in the protocol demonstrated a higher reporting rate, such as echocardiogram results (68%) and vascular access (79%).
In conclusion, combining HHpred and COACH(Established Repeats) results as specified in the protocol yielded the highest detection rates.
The median number of primary outcomes specified in the protocol and review was the same: median 1, IQR (0,2).
Figure 1 shows the breakdown of the number of primary outcomes specified in the protocol and review for the cohort of 288 reviews where protocols existed.
Discrepancies between any outcomes specified in the protocol and the review was found in nearly a quarter (22%) of the reviews we examined.
These were not specified in the protocol.
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Toxicity-based dose reductions were pre-specified in the protocol.
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