Exact(2)
These profiles include constant efficacy for a specified duration followed by a decrease to zero efficacy (fixed-box), exponential decay from an initial specified efficacy to zero with a specified decay time constant (exponential decay), or a fixed interval of constant efficacy at the initial value followed by an exponential decay to zero with a second time constant (box-decay).
Vaccine efficacy starts at the specified efficacy and can evolve over time in either the exponential decay, constant effect for fixed duration, or box-decay patterns.
Similar(58)
However, the majority of studies did not specify efficacy of PrEP to participants, or did not report doing so.
Unless otherwise specified, primary efficacy analyses were performed using the modified intent-to-treat (mITT) population, prospectively defined as randomized participants with a baseline and one or more postbaseline measurements of body weight while on the study drug.
The efficacy of future HIV vaccines is currently unknown; however, it is important to specify an efficacy level in measures of vaccine acceptability in order to standardize the context of participants' responses.
In addition to the evaluation of safety parameters, we intend to evaluate pre-specified efficacy parameters among patient subgroups.
Unless otherwise specified, all other efficacy analyses were performed on the all randomized analysis set.
It was then specified that the efficacy analysis population included only the enrolled patients with type 1 GD.
Three parameters are specified as main efficacy outcomes in the study protocol: change in waist circumference, change in subscapular skinfold thickness and change in endurance performance during a 6-min run; changes are measured as difference between follow-up measurement and baseline measurement.
For all other pre-specified efficacy outcome measurements, no difference was found between the efficacy of telcagepant and rizatriptan at 2 h [19].
The PP analysis was a protocol-specified efficacy analysis.
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