The trial was not designed to detect specified differences in secondary measures a priori.
Main Outcome Measures: Mortality, HbF levels, painful episodes, acute chest syndrome, and blood cell counts, The randomized trial was not designed to detect specified differences in mortality.
Using an effect size of 1.4 seconds (obtained from a pilot study and literature review) and alpha level of 0.05, the sample size of 25 subjects was calculated to have a 99% power to detect the specified difference in outcome.
In contrast, trials investigating whether glycaemia were lowered more by one treatment than another, for example, by different insulin regimens but without specifying differences in glucose targets or intentions with respect to differences in glucose levels, were excluded.
Variations in the adhesive properties of Type I fimbriae are characterized by either high (M1H) or low (M1L) affinity mannose binding, which may specify differences in host cell binding [ 24, 25].
Unless otherwise specified, differences cited in the text as statistically significant met the P < .05 threshold.
It was agreed to power the study to detect the pre-specified differences in the primary outcomes in the sub group of women with two or more social risk factors, which lead to an increase in the sample size to 658 women per arm.
These cases were modified to suit the three types of services (primary care, A&E, and community mental health) and aimed to specify differences and similarities in treatment for migrants in comparison to indigenous populations (as can be seen in the text from the vignettes below).
The two groups can be specified by differences in income, education and power, but Murray's concern is differences in values.
However, the respective CIN rate for each GBCA was not specified, and differences in renal toxicity between these GBCAs therefore cannot be excluded.
In other words, they regard the difference between the price specified in the contract and the sum of the disbursements as the measure of recovery, and they insist that if the aggregate of disbursements equals or exceeds the contract price there can be no recovery at all.
