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The major adaptor proteins (p47/Ufd1/Npl4) broadly determine VCP function, with the precise pathway specified by interaction with further specific coadaptors and/or substrates that can be controlled through dephosphorylation of VCP (Lavoie et al., 2000; Zhao et al., 2007).
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These results challenge some conventional concepts of recognition, particularly the finding that triplets containing 5′A, C, or T are typically not specified by direct interaction with the amino acid in position 6 of the recognition helix.
It is possible that the cross-talk between these two hormones are specified by the interaction between GR and specific transcription factors.
H4 and the dileucine motif have little or no interaction with the Nef core, and their conformation seems to be specified by their interactions with α σ2.
Even then, the subject at hand can only be specified by personal interactions and the meaning of the same matter varies from one to another.
The first is involved in the collapse of the random-coil-like polypeptide chain into a nonnative helical intermediate mainly specified by local interactions, whereas the second is associated with the transformation into the native β-structure, with the helical conformation disrupted by long-range interactions [37] [43].
Rod photoreceptors are specified by the concerted interaction of Crx with Nrl (13, 19) and the nuclear orphan receptor Nr2e3 (18).
This idea assumes that the identity of the different perianth organs is specified by the combinatorial interaction of four DEF-like MADS-box genes with other floral homeotic genes (Mondragón-Palomino and Theißen 2008, 2009).
In cases where a valid interaction detection method was not specified by the source database, the interactions are assigned to 'unknown' method and consequently given a poor score.
The regulatory interactions specified by this genotype allow a circuit to form different patterns of gene expression that constitute a circuit's phenotype(s) and embody its function(s).
This interaction was further specified by a delay × electrode × TF × impulsivity interaction (F2.7,43.8 = 4.33, P < 0.05, η = 0.21).
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