In our study, the proportion of morning headaches resolving within 4 h, that is, the duration specified by the ICHD-3 beta criteria, increased to 52.1%%.
Finally, the parameter of headache days could have used more sensitive definition, such as days with moderate or severe headache specified by not only intensity but also duration.
A direct comparison of these data with our study is not completely possible because some characteristics of patients, such as age and disease duration, were not specified by Grundström et al. Our study includes the first direct comparison of the effects of different anti-TNF α agents on Treg levels.
The duration of the incubation period, as specified by the hazard function parameters (μi, σi) was also found to have a significant influence on the model predictions.
Unfortunately, the duration of action is not always specified by the manufacturer or deducible from pharmacokinetic studies.
Unlike the variances in rates specified by the correlated rates model, which depend on branch duration, σ2 provides a simpler estimate of rate variation.
Similarly, it could also be considered to incorporate some references to the duration and frequency of the sleep difficulties specified by the MISS items, possibly by integrating this with the response options.
The data time span used for fitting is specified by the user, and is generally taken equal to the duration of the sucrose application, up to the time when the sucrose concentration starts to decay back to baseline.
The fictitious actual durations in this phase are generated within limits specified by the phase I parameter (delta_{text{I}} = { 0.2,0.4,0.6,0.8}).
Three characteristics (volume, duration, and peak intensity) are modeled by a multivariate distribution specified by three marginal distributions and a dependence structure via copula.
