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The results demonstrated high specificity, with sensitivity as low as 6 fmol.
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The optimum cut-off point was determined as the value corresponding to the greatest accuracy (i.e. highest summed value for sensitivity plus specificity values, with sensitivity and specificity weighted equally).
Other biomarkers displayed similar specificity, with decreasing sensitivity.
At this cut-off point, IP-10 showed 93.5% of specificity with a sensitivity of 91.8%.
Meanwhile, the Western blot method is characterized by high specificity with lower sensitivity.
The changes in single variables in the iNPH grading scale after TT showed high specificity with low sensitivity.
Tag SNP rs2395185 captured haplotypes involving all DR4 specificities and DR9 specificity with a sensitivity of 98.5% and specificity of 94.9%.
Thus, the present study revealed a high specificity with low sensitivity in each domain of iNPHGS, which agrees with previous reports [ 3, 7, 8].
For the 101 samples, the ArrayTube had a sensitivity of 91.7% and a specificity of 100% compared with sensitivity and specificity of qRT-PCR (Technical Appendix Table).
Currently, the McDonald criteria used for MS diagnosis have specificity over 90% with sensitivity of 77% and accuracy of 86%.
This meta-analysis demonstrates that LiPA yielded high overall sensitivity and specificity with a maximum joint sensitivity and specificity of 97% (based on the Q* index).
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