TSG hypermethylation in cancer cells has strong specificity with respect to the tissue of origin and tumor-type-specific methylation patterns have been reported for primary human tumors and cancer cell lines [ 7- 11].
Paramount considerations for PEGylation reactions are specificity with respect to the conjugation site and overall yield.
This specificity with respect to a conventional chemical system is shown.
Gender specificity with respect to land-use options and responsiveness to agents that offer related investment opportunities is poorly understood.
The primers and probes were assessed for their specificity with respect to known splice variants and single-nucleotide polymorphism positions documented in transcript and single-nucleotide polymorphism databases.
Thus, MrSGT differs from the S. tropica-derived SGT in its strict substrate specificity with respect to the glycosyl moiety donor.
The constraints on activity and RAR-type specificity with respect to the structural link between the polar and non-polar functions of synthetic retinoids are poorly understood.
This task was undertaken with the aim to obtain new compounds with an enhanced antiproliferative activity and, possibly, a different specificity with respect to the original (lead) compound.
However, the methods for validating evaluation checklists are less commonly presented and lack specificity with respect to study designs and outcomes.
Due to its generally higher speed, sensitivity, reproducibility and specificity with respect to HPLC, it can be used to simultaneously separate and determinate multi component steroid mixtures.
This indicates that a human cancer compendium lacks specificity with respect to a breast cancer compendium.
