The interaction between histones and DNA is typically a high-affinity, low-specificity type of binding, which leads to the formation of non-specific aggregates when histones and DNA are mixed at physiological salt concentrations.
The extreme level of genetic diversity characteristic of the HLA loci prevents the achievement of high-sensitivity and high-specificity typing of the over 2,000 class I HLA-A, -B, and -C alleles reported worldwide.
The lacking specificity regarding type of antibiotic exposure may also have contributed to an increased risk of a type 2 error.
The workgroup submitted recommendations on the measurement of circulating insulin including the assay specificity, optimal type of sample, standardization of the assay, and manner of reporting results.
The specificity and type of ubiquitination is generated from substrate recognition by the E3 and the formation of different E2 E3 complex combinations that mediate ubiquitination (Weissman 2001).
Furthermore, organ specificity, cell specificity, types and incidences of biologically adverse events, in vivo distribution, and other factors must be examined.
Last time we were being introduced to the specificities of type of Hollywood "The Comeback" depicts, whereas now we cringed because we were already familiar with the torture (both self-inflicted and industry-inflicted) that Valerie encounters.
Moreover, to maximize efficiency and specificity, multiple types of ligands can be conjugated to the particle surface.
The current study sheds light on the structural basis of substrate specificity of type-II FPPS of the spruce budworm.
Of course given the number of observations and the specificity of this type of food innovation we are carefully constrained in drawing more general conclusions.
