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These findings demonstrate the need to develop site-specific endonucleases with high specificity to avoid unwanted gene alterations.
This is a major challenge since most dementias associated with brain inflammation are curable if identified early, and underscores the need for a diagnostic test of high specificity to avoid misdiagnosis as sCJD for which there is currently no treatment.
If we are considering the general population for whom the risk of ARM-related vision loss is less than 1% over their lifetime, then the current genetic models have inadequate levels of specificity to avoid a high percentage of false positive results.
A screening test for Barrett's oesophagus should have high specificity to avoid unnecessary confirmatory endoscopies or interventions.
However, when screening, better tests must increase sensitivity at high specificity to avoid numerous false-positives [ 15].
It is desirable to have a screening tool with high sensitivity but it is also important to have high specificity to avoid unnecessary radiographic examinations.
Similar(40)
However, unlike the Bayesian classifier, we use a sum of weighted probabilities (specificities) to avoid the problems caused when a pattern is not expressed at all in a given condition (the Bayesian product of probabilities would be zero).
The cDNA was amplified with gene-specific primer pairs located on two adjacent exons to achieve a high level of specificity and to avoid detection of genomic DNA.
For additional specificity and to avoid cutting within the array itself (autoimmunity), RNA-guided Cas9 cleavage requires a protospacer adjacent motif (PAM; in S. pyogenes: 5′-NGG-3′) flanking the target site.
Of course the question arises at what point of specificity to stop to avoid overfitting of the models and to cease the otherwise neverending task of subjective tests.
This compound, SR9238, was designed to display liver specificity so as to avoid potential detrimental effects on reverse cholesterol transport in peripheral tissues.
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CEO of Professional Science Editing for Scientists @ prosciediting.com