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However, additional statistical power is gained in the Uncertainty and Specificity statistics with increasing number of downstream gene expressions in a HYP, such that the weaker scores of larger HYPs can be just as significant and meaningful as higher scores from smaller HYPs.
Sensitivity and specificity statistics were used to determine the ability of classification in the SRRST.
In these studies, associations between professionally assessed treatment need and health status measure summary scores were assessed using sensitivity and specificity statistics.
We ran 30 simulations and the means and standard deviations (SD) of the sensitivity and specificity statistics using the two approaches are reported in Table 3.
The evaluation of predictions requires independent and high quality annotated test sequences against which predictions are compared to determine sensitivity and specificity statistics and a quantitative evaluation of prediction accuracy.
Together, the Uncertainty and Specificity statistics enable the identification of non-specific and non-significant scores in HYPs when scored against unrelated perturbations.
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We agree that a more insightful discussion centers on interesting recent work that attempts to rigorously interrogate the pain specificity of statistics maps by using multivariate pattern analysis (MVPA), as we and others have been doing (see: Brodersen et al., 2012; Brown et al., 2011; Duff et al., 2015; Marquand et al., 2010; Wager, 2015; Wager et al., 2013).
The key point of this type of approach is to exemplify spectrum-specificity via spectrum-specific score statistics.
Under scenario (a) with high sensitivity and specificity, all the statistics are influenced by prevalence, B-statistic and AC1-index behave similarly and are less affected by prevalence indices closer to 0 and 1.
Correspondingly, the sensitivity, specificity, and kappa statistics of TTH ≥1 day per month were 96%, 69%, and 0.44.
Sensitivity, specificity, and κ statistics were calculated for the medical records and were compared with patient interviews for the presence and severity of symptoms.
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