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These results confirm recent findings that HLA class I supertypes often provide an oversimplification of the HLA class I specificity space [24], [40], [41].
Two groundbreaking studies aimed at addressing this controversy found very limited binding overlap and proposed that PDZs are evenly distributed across the ligand specificity space [10], [14].
Our method is a valuable tool for exploring the specificity space of PRDs.
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In this paper, we formulate a theory of risk of on-orbit obsolescence by building on the traditional notion of obsolescence and adapting it to the specificities of space systems.
However, concerns exist about the specificity of space-time syndromic surveillance, i.e. that it might generate many false signals [8], [9].
The specificity of SPACE-HRM is tested compared with these two standard methods.
There were five false-positive MR interpretations of medial meniscal tear for both reader 1 and 2 using 3D SPACE (specificity 69%%) (Fig. 1).
One study plotted only summary estimates of sensitivity and specificity in ROC space, with no SROC curves.
The results suggested that TR gained the ability to bind to conserved half-site repeats in a common ancestor, but did not subsequently evolve a distinct specificity as regards spacing between half sites.
The sensitivity and specificity of MCP joint space distance for the detection of erosions were 85.4% versus 55.2%.
The conventional SA search scheme is replaced by a new design that takes into account the specificity of the solution space of project scheduling problems.
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