Sentence examples for specificity shift from inspiring English sources

Several mutations cause a substrate specificity shift from the preferred substrate of the enzyme, glutaryl-7-ACA, towards the desired substrate, adipyl-7-ADCA.

The new system gained about 1200-fold cofactor specificity shift from NAD toward B-8 in terms of oxidative decarboxylation of l-malate.

The specificity shift appears to be driven by binding forces and restrictions that dictate which end of a peptide each enzyme can accommodate; the enzyme chemistry for both is the same.

At least in the latter version there appears to have been a specificity shift towards dsRNA from the likely ancestral pPIWI preference for binding DNA/RNA hybrid duplexes [ 20, 22, 29].

By exchanging these two flanking amino acids (Val66Ala, Met163Leu) in hsCK2α1 335, a C-terminally truncated variant of hsCK2α, the cosubstrate specificity shifted in the expected direction so that the mutant strongly favours ATP.

Here also both the sensitivity and specificity shifted toward negative and positive thresholds respectively (table 4).

Perhaps during remission, ACPA specificity shifts in some subtle but significant way to nonpathogenic species.

In contrast, the specificity shifted to +1R in the fungal lineage leading to the ancestor of the IME2 kinases (i.e., AncIME2).

It is unclear whether T cells display constant specificity to a certain form (native or posttranslationally modified) of the CII259-273 epitore or if T cell specificity shifts at different time points during disease development.

Similar behavior has also been reported for Zymomonas mobilis levansucrase, where the product specificity shifted from levan to FOS when the sucrose concentration was increased to 800 mM [ 23].

In addition, olfactory-specific gene families might contribute to the host-specificity shifts occurring in the diversification of super-specialist Drosophila species [ 8, 9].