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Seven additional papers were identified in our specificity search although none were selected for review.
The 2 new strategies seemed to work well except for the sensitivities from the high specificity search strategies.
However, if the desired target has no unique segments, the primer specificity search would run indefinitely, thus slowing down the primer generation procedure.
To ensure specificity, search parameters were set to a word-size (W) of 5 and gap open (G) and gap extension (E) penalties of 50.
Except for the sensitivities of the high specificity search strategies, the other performance characteristics of the new strategies developed using both the random sampling and top journal approaches were close to those of the existing search strategies (Table 3).
This selection somewhat enriches the sample of target articles (those that "pass" for scientific merit) thereby improving the estimates of the sensitivity and specificity search term performance and simplifying data processing.
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These tools are smart enough to get around the classic search engine failing of excessive specificity: searching for "dog" and missing all the articles that have only "canine" in them.
In addition, the reference lists and journal publication websites of the papers sent for full appraisal were hand-searched for additional references, and specificity searches using the identified tools/models names were performed.
Using both refined search strategies and broad spectrum, low specificity, searches (i.e. " Streptococcus pneumoniae" OR "pneumococcus" anywhere in the text), we reviewed all references on S. pneumoniae that were geographically linked to LAC countries, with no language restrictions; the targeted age group was children 6 years-old or younger.
The current PubMed CAM filter has several non-specific search terms that contribute to the lack of specificity of search output and that identify some irrelevant studies as "CAM", such as plant-derived compounds in chemotherapy [ 20].
What he is excited about, though, is marrying the brand advertising of video with the specificity of search.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com