The Bradford Hill criteria include an examination of the strength of the association between the risk factor and the disease, as well as the consistency, specificity, relationship in time, biological plausibility and experimental evidence, and whether greater exposure is associated with more disease.
Using this recombinant protein, polyclonal antibody was generated and investigated for its specificity, relationship to enzyme activity and the possibility of immunohistochemical measurement of tumoral DPD.
The specificity relationships were unchanged in the secondary analysis (Additional file 1 Table S4).
The application of macroarrays to piroplasm discrimination would help to investigate the host susceptibility and parasite-host specificity relationships.
Unfortunately, a lack of knowledge of the sequence-to-specificity relationships in CAZy families does not yet allow a reliable, automated substrate prediction [ 2] for the esterases within a CE family.
Along with probe specificity, the relationship between the 3' and 5' location of the mismatches was also assayed.
Elevated autophagy has been reported after spinal cord injury (SCI); however, its mechanism, cell type specificity and relationship to cell death are unknown.
Amyloid binding on PET has been shown to be strongly correlated with brain Aβ burden at autopsy, and PET imaging identified amyloid-positive subjects with a high sensitivity and specificity in relationship to postmortem histopathological criteria for AD.
Among them (strength and consistency of the association, specificity, temporal relationship, plausibility, coherence, experiment and analogy), the Normoglycemia in Intensive Care Evaluation and Survival Using Glucose Algorithm Regulation (NICE-SUGAR) investigators have already evidenced specificity because the association was strongest for death from distributive shock [ 13].
In some instances, this apparent contrast among study results was explained by the different origin of the patients included; eg, when patients from stroke clinics are compared with patients from memory clinics, the specificity of relationship between neuroimaging and functional data is much weaker in the latter group (Rockwood et al 2006).
First, the genomics data are heterogeneous in their sensitivity and specificity for relationships between genes.
