Sentence examples for specificity problem from inspiring English sources

To overcome the specificity problem, a comprehensive footprinting approach was formulated to identify TF-specific operator motifs and was applied to the LacI-family of TFs in the model gram positive organism, Lactobacillus plantarum WCFS1.

To gain a better understanding of this oxime specificity problem for future design of improved reactivators, we conducted a QSAR analysis for oxime reactivation of AChE inhibited by OP agents and their analogues.

Among these are the specificity problem the need to engineer preference for the intended assembly geometry over all alternatives, and the folding problem — understanding what thermodynamic or kinetic features of assembly subunits and inter-subunit interfaces lead to successfully folding superstructures and how to encode these in the amino-acid sequence.

Complicating the Hox specificity problem is that this family of proteins, which are encoded by eight Hox paralogs in Drosophila and 39 Hox genes in vertebrates, all bind to very similar DNA sequences via identical DNA-contacting residues in their homeodomains [19], [20], [21], [22].

BJ-TSA-9 also suffers from the same tissue specificity problem that plagues CEA and CK19.

However, it does not address the specificity problem adequately, as the positive predictive value does not change.

In addition, it is also important to remember that test parameters are population specific and it is a well recognized problem that diagnostic test can have specificity problems when applied in an African context [ 42].

The structural conservation of kinases causes specificity problems in most drug inhibitors, often resulting in dangerous side effects.

However, in addition to specificity problems, serologic tests for early Lyme disease can be falsely negative due to lack of sensitivity of ELISAs and Western blots.

In order to test whether the low accumulation of the NIRF-Annexin V probe in the treated tumors was due to the specificity problems of the probe or due to a reduced delivery at the target site (as a consequence of the therapy-induced vascular breakdown), a second therapy study was performed applying a similar therapy design.

For example, manipulating the mode of self-focus influences autobiographical memory specificity, problem-solving ability, and emotional recovery from a laboratory-induced negative event, where relative to analytical self-focus, experiential self-focus has more adaptive effects (Sanders & Lam, 2010; Watkins, 2004; Watkins & Moulds, 2005; Watkins & Teasdale, 2004).