Sentence examples for specificity position from inspiring English sources

By coloring nodes according to the identity of an important catalytic or specificity position, sequence similarity networks show a clear utility in tracking functional changes with a protein subfamily.

The site with the lowest contribution to specificity (position 135) was substituted to a basic residue in Fundulus (K) and medaka (H) (Additional file 1: Figure S1C).

In the modified AC search terms the amino acid residues that confer substrate specificity (position 3 in Figure 1) will be substituted to [DE].

In the loop-closed state, the specificity loop adopts an LDH-like confirmation with Trp107f occupying the specificity position and Arg102 oriented into solution, similar to how Lys102 is positioned in the modern and ancestral LDH structures.

We focused on genes that were identified by the previous LIGAP analysis and considered all transcription factors that had known binding specificities (position specific frequency matrices, PSFMs) in TRANSFAC [ 77] (version 2009.3).

Nonetheless, studying the binding profiles at these low specificity positions raises the question of whether these differences are meaningful at all.

Some protein factors homologous to their counterparts in other organisms show differences in their RNA-binding specificity, positioning, and function.

Although these second category methods demonstrate very high specificity (positions without variance are correctly identified as such), sensitivity (pinpointing true variant positions) remains the major limiting factor (Wilm et al., 2012).

To assess whether these significantly contributed to the DSE specificity, positions 4 and 6 in the human DSE matrix and position 2 in Drosophila DSE were replaced with background nucleotide frequency.

In spite of these similarities, Torkamani's method does not benefit from intra-family specificity positions or from GO annotations, which we have shown to be crucial for prediction (see above).

Moreover peptoid monomers of Nlys and Nphe introduced in the substrate specificity P1 position of monocyclic SFTI-1 preserved trypsin and chymotripsin inhibitory activity respectively and made P1 P1′ bond proteolytically stable.