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Exact(43)
Early studies found sensitivity and specificity of this test to be extremely high (over 90% sensitive and specific) [ 4], although other studies, particularly in endoscopy-negative patients, report lower accuracy of the pH-metry [ 5].
Unchanged orthostatic blood pressure response in patients with migraine may be associated with the limited specificity of this test.
Specificity of this test was demonstrated and its usefulness appeared directly dependent on conditions supporting hepatic cell competence.
Clinical research and recent brain imaging have brought into question the validity and specificity of this test as a marker of frontal dysfunction.
The relative insensitivity of the orthostatic load in migraine can be explained by the limited specificity of this test for evaluation of the vascular reactivity because compensation of the orthostatic load is mediated by various mechanisms, and most of them do not directly require activation of the sympathetic nervous system.
Although inflammatory activity is well appreciated on images, morphologic assessment is limited because of the relatively low special resolution; thus, nuclear imaging studies receive substantial benefit when obtained in conjunction with either CT or MRI, increasing the sensitivity and specificity of this test [12, 13, 14].
Similar(17)
The sole stated basis for the diagnosis was a positive Western blot result, but neither the interpretive criteria used nor the specificity of this testing were provided.
In addition, sensitivities and specificities of this test and of the HEV IgM ELISA 3.0 (MP Diagnostics, Singapore) did not differ significantly.
The BinaxNOW results reported in this study are consistent with reported sensitivities and specificities of this test in the literature [ 18, 19].
Use of gentler decontamination techniques can reduce the specificity of the test: this approach protects the acid fast bacilli but fails to prevent contamination from other microorganisms.
Such an approach would focus the use of relatively expensive non-invasive diagnostic imaging tests, such as ultrasound, and would be likely to increase the specificity of this imaging test to diagnose fatty liver, and lead to more cost effective use of limited resources.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com