Sentence examples for specificity of this methodology from inspiring English sources

Controversially, both studies [ 48, 53] using MS-MLPA reported methylation of BRCA2 in a sizeable number of tumors, and this casts doubt on the specificity of this methodology.

It is essential to generate additional data in larger studies in order to test the validity of this proteomic approach to preimplantation aneuploidy detection and to define the real sensitivity and specificity of this methodology.

Although the association of the luminal phenotype with Tamoxifen and ESR1 expression level provides an additional validation of the specificity of the methodology, a more pressing question in the context of breast cancer therapy is the basal phenotype since effective treatments for this group of patients are limited.

Third, the retrieval performance to measure sensitivity and specificity of the methodology filters was not tested.

We also constructed a negative dataset (a benchmark dataset is not available for such studies) to assess the specificity of the methodology.

The specificity of the methodology was validated (1) by the use of neutralizing anti-receptor antibodies, which block the ligand-binding site on the receptors; (2) by the use of an irrelevant ligand (PDGFB); and finally (3) by performing kinetic analyses that showed disappearance of the PLA spots with time, in conjunction with ligand-induced internalization of receptors.

To validate the specificity and sensitivity of this methodology, we applied the screening assay to cellular conditions and proteins of interest known to regulate macropinocytosis.

Overall, the well-based RPPA showed great sensitivity and specificity, especially this methodology could be used substantial HER-2 expression status confirmation assay with advantages of excellent positive predictive value (94.6%) (Table  1).

We show a remarkable overlap between age-related DMRs from the same stage of the life course in multiple data sets, attesting the specificity of our methodology.

Indeed, we were intrigued to indirectly validate the strength of this methodology through uncovering a correlation of ligand stereoelectronic control with receptor subtype specificity for the Proteolytically Activated PAR1 and PAR4 receptor subtypes.

The main specificity of the proposed methodology lies in the algorithm for calculation of stress histories in the stirrups and in the web concrete.