Two PD diagnoses were mandated to increase the specificity of this inclusion criterion.
Use of MAGNIMS-based imaging criteria for PPMS with or without associated CSF evaluation should be supported by additional data further documenting the sensitivity and specificity of the criteria in this population.
The high specificity of the criteria reported in this study relates to a single uncontrolled screening block.
However, we observed that the low sensitivity and high specificity of these criteria persisted even when limited in this manner.
Although previous definitions of sepsis required only 2 SIRS criteria, the PROWESS trial investigators required the presence of ≥3 SIRS criteria to improve the sensitivity and specificity of these criteria for the diagnosis of sepsis.
In addition, the sensitivity and specificity of the criteria used to define influenza-like illness declines with increasing age due to atypical presentations of illness and the inability to distinguish between influenza and other respiratory viruses.
The presence of fewer migrainous features among subjects diagnosed with TTH using the alternative criteria may imply higher specificity of these criteria, compared to the standard criteria.
However, the precise specificity of these criteria and their performance for the early diagnosis of other target diseases involving growth monitoring must be tested.
By combination of all parameters, sensitivity is 98% and specificity of the criteria is 71%.
20 However, the specificity of the criteria has not been fully examined as yet.
