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However, there is inconclusive evidence in the peer-review literature on the specificity of these techniques in the evaluation of the effect of corneal cross-linking [ 8].
In order to assess fully the sensitivity and specificity of these techniques, the cohort presented in this study should be regarded as a training set.
The sensitivity and specificity of these techniques are comparable to those of PCR-based diagnostics, although the specificity of LAMP decreases because of non-targeted amplification.
Together, these issues revolve around the lack of specificity of these techniques despite high sensitivity for detection of bone metabolism, which may not be associated with oncological phenomenon.
While the laboratory analytical sensitivity and specificity of these techniques for the detection of pathogen DNA in blood has been evaluated, 12 there remains an acknowledged lack of clinical trial data to define the diagnostic reliability of such tests in patients who develop a systemic inflammatory response due to suspected infection.
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However, sensitivity and specificity of those techniques are suboptimal and prompt the need for more accurate biomarkers.
The chapter includes a brief descriptions of the working principles and specificities of these techniques in various (especially newly developed) formats.
Comparative studies of the sensitivity and specificity of these diagnostic techniques are necessary.
The main objective of this study was to determine the sensitivity and specificity of these two techniques for the diagnosis of CR-BSIs in newborns from a neonatal ICU.
Other explanations for the discrepancies in microchimerism results are differences in experimental designs and the sensitivity and specificity of the techniques used by different investigators [18].
However, almost without exception in these studies, the specificity of the technique was not evaluated using an XIAP-deficient or null matrix, such as the low QC used in the present study, the X-G4 clone stably transfected with a vector containing an siRNA to XIAP.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com