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This motivated Schlicker et al. [ 44] to refine the measure by weighting it by a factor accounting for the specificity of the terms: where is the probability of the most informative common ancestor of and.
To remedy this, Lin normalized the measure between 0 (no similarity) and 1 (identical) [ 42]: But due to the normalization, Lin's measure does not convey the specificity of the terms compared.
In order to study the level of specificity of the terms to which Evo-Bexpa biclusters have been annotated we have carried out three different validations: taking the whole hierarchical graph into account, and limiting the validation with the levels 3 to 6 and 4 to 7, both inclusive.
The results of the first BioCreative challenge suggest that a combination of several factors can influence the performance of text mining systems in the extraction of GO terms associated with defined genes, including the specificity of the terms and their GO branch membership (36).
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At a time when clinical remission has become an achievable goal, another issue is of importance: the specificity of the term 'remission'remission
The remaining terms were associated with a relatively small number of genes (median of 19 genes per term, including genes associated with descendent terms), indicating the high specificity of these terms.
Boolean operators were used to combine search terms as necessary, and the MeSH subheadings tree was used to increase the specificity of the search terms in MEDLINE and EMBASE databases.
This can be advocated by the fact that the sequence diversity is inversely proportional to the specificity of the GO terms.
Thus, the proportion of the annotation size of a GO term to the total number of annotated proteins can quantify the specificity of the GO term.
The proportion of the annotation size of a GO term (Si p,q)) to the total number of annotated proteins (Smax) can quantify the specificity of the GO term.
In general, a lower frequency means a higher specificity of the functional term for the two proteins.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com