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Liquid chromatography tandem mass spectrometry has become increasingly popular in clinical laboratories over the last decade due to the inherent sensitivity and specificity of the technology.
To validate the sensitivity and the specificity of the technology, we evaluated human cell lines with known viral infections.
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In the study, we introduced time differences for displacement, strain, and strain rate changes as indicators of arterial stiffness because of the specificity of this technology.
More than 81% of amplicons suspected to have a sequence variant after HRM analysis carried one after sequencing, confirming the specificity of this technology.
In addition, it has been recently demonstrated using a genetic approach that the specific inhibition of ChoKα by shRNA displays antiproliferative and antitumoral activity The high specificity of this technology provides definitive evidence of an antitumoral strategy based on ChoKα inhibition, supporting previous results with the pharmacological inhibitors.
Indeed, the specificity of the PCI technology was confirmed by demonstrating no weight loss of animals or other side effects that were subjected to PCI of scFvMEL/rGel.
In addition, we performed a set of controls to further validate the specificity of the PLA technology.
In this sense, although the throughput of macroarrays is moderate as compared to microarrays, the former represent a cost-effective, rapid, accurate, and efficient alternative that do not require specialized equipment and can be used in any well set-up molecular laboratory but still retain the sensitivity and specificity of the microarray technology.
Our formulation captures the specificity of each technology in terms of the power model and radio resource allocation.
And the company maintains that the specificity of their technology could have significant environmental benefits.
Therefore, we feel that the parameters that we identified ensure an adequate balance between sensitivity and specificity of castPCR technology for the use in clinical samples.
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