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These weighting factors allowed us to increase the specificity of the program for a selected pattern, thereby eliminating false positives, or conversely, increasing the number of hits, though potentially at the cost of more false positives.
The specificity of the program's mission not only impacts upon the types of services offered but can also affect a program's ability to expand and adapt into new settings.
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To assess the sensitivity and specificity of the programs, we used a list of high-scoring motif sites extracted from the whole-genome sequence of the reference binding-motif sequence for CTCF.
To compare the sensitivities and specificities of the programs, we selected the top-ranked peaks returned by each program and analyzed the number of peaks that contained the canonical motif sequence, in a manner similar to that used by.
The specificity of these programs was high using chicken data.
Thus, we find these "negative" sites and their corollaries in the GABP dataset unreliable for assessing the specificity of the different programs using metrics such as a receiver operator curve (ROC), despite the fact that other groups have used this metric previously [12].
With aging, such "epigenetic memory" of the cellular identity goes awry, contributing to the deterioration of the specificity of transcriptional programs and fidelity of genome maintenance [ 4- 6].
In the present study, considering the specificity of our CART program, we demonstrated the same benefits in a shorter time frame [14].
If every participant attended all five annual screening rounds (100% attendance), the overall specificity of the Pap smear screening program would be less than 86% for CIN2+.
Using discontiguous seeds improves the specificity and sensitivity of the programs.
This demonstrates that these subsets of genes have a higher specificity than either of the programs do individually, and can be considered higher confidence.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com