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The histogram of predicted probabilities shows the specificity of the predictions: there is a large gap between 15% and 55% probability and most possible contacts have probability <15%.
The comprehensiveness of the data in this study enhances the specificity of the predictions over previous studies.
The sensitivity and specificity of the predictions were then compared among the four different sets of wells.
Similarly as in the original study of St Onge et al. [10], the prediction capability was evaluated using the receiver operating characteristic (ROC) curves that show the relative trade-off between the sensitivity and specificity of the predictions at multiple decision thresholds (Figure 3).
Additionally, we calculated the sensitivity and specificity of the predictions.
These filters increased sensitivity and specificity of the predictions, which reduced false negatives and false positives.
Similar(42)
Though using combinations of two or more of these computational approaches may improve the sensitivity or specificity of the prediction, the degree of overlap of their predictions is poor [32].
When a portion of this same intron not corresponding to a computationally predicted CRE was tested by electroporation, it failed to drive any expression in the retina (Fig. 4B), thus demonstrating the specificity of the prediction.
However, the specificity of the prediction is compromised when only group 4 features were used.
Using ApoE status as a co-predictor the specificity of the prediction increases to 95.83% at the expense of the sensitivity which decreases to 66.67%.
At this cutoff, the sensitivity and specificity of the prediction of RRT or death were 43.5% and 95.5%, respectively, and the positive predictive value was 90.9%.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com