Sentence examples for specificity of the engineered from inspiring English sources

A panel of optimal peptide substrates of defined sequence, as well as a degenerate peptide library, was utilized to assess the phospho-acceptor specificity of the engineered "traceable" kinases.

This type of toxicity is a direct result of the specific recognition of a target expressed in normal tissues by CAR-T cells, thus its profile is dependent on the antigenic specificity of the engineered T cell and can be predictably seen in a variety of organ systems (Bonifant et al., 2016; Barrett et al., 2015).

Therefore, to probe the integrin binding specificity of the engineered knottin peptides, competition binding assays were performed with 125I-echistatin and K562 leukemia cells, which naturally express α5β1 integrin, or K562 cells that have been stably transfected to express αvβ3, αvβ5, or αiibβ3 integrin receptors [29].

It is an ideal scaffold for adding more zinc-fingers to its three-zinc-finger domain and obtaining better gene-specificity for the engineered transcription factors because of its accessibility to GC-boxes within chromatin and low antigenicity.

As is observed with the biosensor-blocker HDV ribozyme, the specificity of these engineered nucleic acid molecules was dramatically increased through blocker-mediated inactivation followed by reactivation via an extended complementarity with the appropriate biosensor sequence (Figure 2A C, lanes 4 to 7).

We measured the binding affinity and specificity of this engineered knottin peptide against cell lines expressing particular integrin receptors.

Bone, R., Silen, J.L. & Agard, D.A. Structural plasticity broadens the specificity of an engineered protease.

The substrate specificity of an engineered Bacillus subtilis epoxide hydrolase, which so far had shown high activity and enantioselectivity with 1-benzyloxymethyl-1-methyloxirane, has been studied by altering the methyl substituent into hydrogen, oxygen-containing functionalities, and unsaturated homologs.

Using the established method, positional specificity of several engineered phospholipases D in enzymatic synthesis of PI from myo-inositol and phosphatidylcholine was investigated.

The major challenge currently facing the field is to increase the specificity of engineered T cells for tumors, because targeting shared antigens has the potential to lead to on-target off-tumor toxicities, as observed in recent trials.

Characterizing C domain substrate specificity is important for the engineered biosynthesis of new compounds.