The assessment was not conducted as a specific test of the sensitivity or specificity of the systems, because the underlying algorithms were not reviewed.
The dense packing of aptamers on ACMNPs creates a multivalent effect for target binding that results in high sensitivity and specificity of this system in complex biological systems, including serum, plasma, and whole blood.
The prediction accuracy is negatively affected by the low specificity of all systems here evaluated, as they, on the other hand, reached 100% of sensitivity.
These are typically high affinity transporters that are only expressed during sub micromolar concentrations of extracellular phosphate and the specificity of Pst systems is for protonated phosphate species but not metal phosphates.
We can illustrate the critical importance of sensitivity and specificity of detection systems by considering the anthrax attacks of fall 2001.
Chest radiography is frequently used to assess EVLW, but usually its interpretation is subjective; in addition, the sensitivity and specificity of scoring systems are largely uncertain [ 16, 17].
Even under optimal conditions the realistically achievable specificity of these systems in high burden settings will likely be significantly below that obtained in low TB burden laboratories.
Theoretical specificity of the systems was investigated using BLAST against the NCBI nucleotide database with very loose match criteria (word-size = 7, E-cutoff = 1000, match/mismatch cost +1/-1, gap cost 5/2).
We evaluate the dynamic range and specificity of this system in comparison to other available systems.
