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However, such a priori specificity of simulation becomes increasingly difficult as a concept becomes increasingly abstract (e.g., consider "the basis of freedom" or "world peace").
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To assess the sensitivity and specificity of the GGM approach, we performed a series of simulation studies.
We validated that these changes were previously described not to affect the sensitivity and specificity of the method through coalescent simulations (Pybus et al. 2014).
To demonstrate the stringency and specificity of our criteria, we conducted a simulation analysis to look for random hotspots based on our coverage (See Methods).
We lacked real data to evaluate the performance of our newly developed algorithm, thus we conducted a series of simulations to assess sensitivity and specificity of the approach.
We developed a simulation model of unbiased identification of specificity of 'problematic' ChIP-seq loci.
Randomization simulations also illustrate the specificity of the 21bp tags to detect real transcripts, corroborating previous estimations [ 29, 46, 48, 49, 95, 96].
To separate the diseases which may simply be byproducts of random effects (i.e. mostly the magnitude of TE activity) from those that are the results of the target-specificity of transposition, Monte Carlo simulations were performed to determine the expected number of affected metabolites given the number of observed TE insertions.
Estimates for the sensitivity and specificity of the three tests, determined by Markov chain Monte Carlo simulation, appear in Table 3.
Specificity of these 2 PCRs was verified in silico (computer simulation) and by using a panel of 14 Bartonella species available in our laboratory (data not shown).
In a simulation study they demonstrated that the reduced specificity of the CPUR metric resulted in substantial attenuation of risk estimates.
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