This mRNA rescued the PAC phenotype significantly and almost completely (Fig. 4E-G), demonstrating the specificity of the requirement for dcc.
The aim of these experiments was to determine whether the normal functions of htt would be rate-limiting for particular developmental processes involving the nervous system and therefore indicate specificity of neuronal requirement for htt function.
Thus, the biological response to a given target-derived growth factor depends both on the MN subtype and on timing, offering an interesting context in which to address robustness versus specificity of signalling requirements.
Despite the growing number and specificity of Accreditation Council for Graduate Medical Education curricular requirements, we applaud gastroenterology fellowship training programs for continuing to flourish and remaining responsive to meet these changing demands.
The phosphatase activities of Det1 and YOR283w were further characterized with respect to optimum pH, substrate specificity and requirement of metal cofactors.
According to its hexameric form, substrate specificity and requirement of phosphate for activity, the enzyme proved to belong to the class I of PRPPases.
If the catalysts can be immobilised at otherwise inert anode and cathode materials, this specificity of catalysis obviates the requirement for fuel cell casings and membranes permitting fuel cell configurations amenable to miniaturisation to be adopted.
While prior studies have reported lncRNA induction by endotoxin (Guttman et al., 2009; De Santa et al., 2010), the specificity of the response and requirement of NF-κB were not known.
Neither KPATH nor Insignia is applicable for designing microarray fingerprints, as the design and specificity requirements of microarray fingerprints are quite different from those of PCR signatures.
In order to better define the DNA-binding specificity of AmphiVent1 and spacing requirements, we performed EMSA with AmphiVent1 homeodomain and a series of binding sites (Fig. 8B).
