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A priori the sensitivity or specificity of our methods cannot be determined, although higher specificity might be achieved with the use of very demanding requirements with respect to segregation or case-control disparities.
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High sensitivity and specificity of our method were confirmed with a minimum detection level of 0.1%.
The specificity of our method is demonstrated by the lack of a Yap1p regulon response in H2O2-stressed Δyap1 cells.
In the shuffled data, we are unable to identify any miRNA with significant activity change at 0.30 significance level (q<0.30), suggesting a high specificity of our method.
For example, use of a predefined artefact mask by removing all regions with expected artefacts, might increase the specificity of our method for CMBs in deep and infratentorial regions.
The inhibitory effect persisted for 1 day after a single injection while shRNA-Scramble did not seem to have any effect on the luciferase activity, suggesting the specificity of our method.
This measure serves as a proxy for the specificity of our method.
The high correlation with data obtained by immunohistochemical analysis of MVD proved the specificity of our method.
Otherwise, it is counted as a false-positive prediction when we evaluate the specificity of our method (see Section 3.2).
We used these results to further evaluate the sensitivity and specificity of our method in independent data set tests.
The high degree of overlap between our identifications and the list of previously identified redox-sensitive proteins in eukaryotes makes us confident about the specificity of our method.
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