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The reasons for this include the use of the blood samples as surrogates for the fetus and the specificity of measuring the parent chemical (Lu et al. 2004; Morgan et al. 2004; Wilson et al. 2003).
Our findings may reflect the lack of specificity of measuring adiposity using BMI and waist circumference or may reflect different pathogenic pathways including the type, amount, and distribution of adipose tissue accumulation as well as dietary and genetic influences that may exist among South Asians.
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For example, in those experiments, the RGD peptides were noncovalently functionalized to the AFM cantilevers, which can result in detachment of RGD from the AFM probe during the repeated interactions with the cell surface and render it difficult to ensure specificity of measured rupture forces.
The sensitivity and specificity profile of measuring levels of prostate-specific antigen (PSA) to select men for prostate biopsy is not optimal.
A number of methodological issues, such as the specificity of measure used, characteristics of the population and type of intervention were however, influential in the impact of interventions on outcomes.
Methodological challenges to assessing risk are also presented including lack of reliability and validity of measures, definitional dilemmas, temporal issues such as changes in risk over time, absence of base rate data, predicting for individuals and sensitivity and specificity of measures.
Alternatively, efforts may need to focus on improving both the sensitivity and specificity of measures to target interventions better to the young children most at risk of lasting language problems.
Control experiments should always be carried out to demonstrate the specificity of the measured unbinding forces, which is best achieved by block experiments in which the receptor sites are masked by adding free ligands or by exploiting genetic mutation.
Oligonucleotide lengths and melting temperatures were equalized as much as possible and specificity of amplification measured by melting-curve analysis.
To prove the specificity of the measured interactions, control experiments were performed.
We used the method suggested by the reviewer to determine the specificity of any measured co-localization.
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