Sentence examples for specificity of factors from inspiring English sources

These interactions can either modulate transcription factor activity or contribute to the biological specificity of factors with very similar DNA-interaction motifs.

The molecular basis of the substrate and inhibitor specificity of factor Xa, the serine proteinase of the prothrombinase complex, was investigated by constructing two mutants of human antithrombin (HAT) in which the reactive site loop of the serpin from the P4 P4′ site was replaced with the corresponding residues of the two factor Xa cleavage sites in prothrombin (HAT/Proth-1 and HAT/Proth-2).

Substrate specificity of factor Xa recognizes Ile-Glu/Asp-Gly-Arg sequence and hydrolyzes the bond after the arginine residue [ 20].

An important goal of future research is to decipher the molecular mechanisms underlying the specificity of factor-promoter interaction, both at the level of core promoter recognition and at the level of protein-protein interactions.

Knowledge of the recognition specificity of σ factors and assignment of σ factors to particular promoters is necessary to modulate the effects of sigma factors on the production of specific metabolites.

The specificity of transcription factors contributes to differences in the gene expression of different types of cells.

Contact: [email protected]; [email protected] Until recent years, studying sequence specificity of transcription factors systematically has been limited to a relatively small number of organisms and transcription factors.

To identify the sensitivity and specificity of risk factors for the development of glaucoma in patients with port wine stain (PWS).

These findings underline the importance and the specificity of familial factors in binge eating as compared to other eating disorders and obesity.

Our results here not only explain in part the apparent redundancy in the DNA binding specificity of transcription factors – TFs with similar binding have dissimilar expression pattern – but also underscore the importance of incorporating the expression of the transcription factor genes in the analysis of transcriptional regulation.

Finally, it has previously been suggested that the DNA-binding specificity of Forkhead factors is partially determined by highly variable sequences in the wings W1 and W2 that could adopt specific conformations and guide the precise positioning of the H3 recognition Helix during DNA binding [38].