This approach is simple but has the drawback of not taking into account the specificity of inter-view estimation and cannot assure the best performance.
The non-significant genes contained expected false positives such as TTN and MUC16 or CSMD1[ 16], highlighting the specificity of the FRR estimation.
The specificity of the method (specificity estimation close to 75% based on both local studies) with a 5% precision; The area under the receiver operating characteristic (ROC) curve (estimation of 0.8) with an α risk of 5% and a precision of 0.02.
Hepatocellular carcinoma-AFP-routine test showed diagnostic accuracy for liver cirrhosis vs HCC with ROC curves of 0.99%, sensitivity of 97%, and specificity of 96% in the estimation, and 0.95%, 90%, and 83%, respectively, in the validation.
This sample size will also allow a precise quantification of: The specificity of the method (specificity estimation close to 75% based on both local studies) with a 5% precision; The area under the receiver operating characteristic (ROC) curve (estimation of 0.8) with an α risk of 5% and a precision of 0.02.
Receiver operating characteristic curves of simplified HCC-ART showed AUC of 0.95, sensitivity of 92%, and specificity of 91% in the estimation group.
Receiver operating characteristic curves of simplified HCC-ART (without coefficient) showed AUC of 0.95, sensitivity of 92%, and specificity of 91% in the estimation group, and 0.91, 83%, and 86%, respectively, in the validation group.
These observations suggest that heterogeneity between the protective IDDM2 lineages could exist, and analyzing both −23HphI and −2221MspI would thus potentially enhance the sensitivity and specificity of type 1 diabetes risk estimation.
b) Inaccurate estimation of sequence specificity of RNase digestion.
The overall procedure includes three key steps: (1) pre-processing of CLIP amplicons, (2) estimation of sequence specificity of RNase digestion, and (3) prediction of RNA binding regions.
