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The organ specificity of effect of DFMO results, in part, from the different timetables for cellular events in tissue development displayed by each organ type; administration of DFMO earlier in development (during days 15 to 17 of gestation) did produce deficiencies in cardiac growth and nucleic acid levels similar to those which had been seen for brain and kidney.
Such specificity of effect conforms with the notion that the regulatory mechanisms of hypercapnic and hypoxic ventilatory responses are functionally separated and genetically dissociated in mice [31].
It would be of benefit for future studies that seek to evaluate interventions to use comparable stringent criteria to maximise the specificity of effect.
To confirm the specificity of effect of amiodarone treatment on NSCs and rule out the possibility that the different media contributed to the protection seen for dopaminergic neurons, we derived neurons in defined media [11] and treated them with amiodarone HCL.
This study is inherently predicated on the specificity of effect of the RIP::IGF-1 transgene employed.
Additional file 2: Comparison with unconverted DNA showed specificity of effect of bisulfite-conversion on C% content changes.
Similar(48)
Our findings help clarify uncertainty in the existing literature on the specificity of effects.
The specificity of effects is more readily explained in terms of two-state water.
This review therefore provides little clarity on specificity of effects.
TEs often manifest lineage- and tissue specificity of effects.
Analysis of the symptom dimensions appeared to indicate some preliminary evidence for specificity of effects.
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