Sentence examples for specificity of compounds from inspiring English sources
Beside a critical role in nicotine addiction, the role of nicotinic receptors in cognitive or emotional processes remains difficult to elucidate, mostly because of a lack of specificity of compounds and because they up or down regulate easily.
The data of Table 1 show that the investigated compounds demonstrated lower inhibition constants for CA II and higher CA II vs. CA I specificity of compounds (3) and (4) versus compounds (5) and (6).
These 12 compounds had no effect on the interaction between lysyl-tRNA synthetase (KRS) and superoxide dismutase 1 (SOD1) [33] indicating the specificity of compounds.
In particular, there are concerns about the specificity of compounds currently used as NADPH oxidase inhibitors.
However, the elusive mechanisms of action and limited specificity of compounds hamper their further application in clinical practice.
Current drug screening and chemopreventatitive methods are suboptimal, due in part to the poor specificity of compounds for cancer cells.
To probe the specificity of compound B toward the Ndc80488 complex, we examined its ability to inhibit MT binding of recombinant CLIP-170488, a MT plus-end tracking protein.
Sensitivity and specificity of compound covariate predictor (CCP), Bayesian compound covariate predictor (BCC), linear discriminator analysis (LDA), nearest centroid classification (NC), and support vector machines (SVM).
The authors developed a homology model of estrogen-related receptor alpha in an antagonist conformation to explain the specificity of compound A. Subsequently, Chisamore et al demonstrated that compound A decreased expression of estrogen-related receptor alpha-responsive genes that encode TFF1, osteopontin, and aromatase.
Despite the potency and specificity of compound 7b to induce apoptosis in K562 leukemia cells, our results also elucidated the molecular mechanisms involved in the cell death pathway and the proposed sequence of events elicited by compound 7b that culminated in cell death is presented in the Scheme I.
The distinct binding modes of compound 1 to STAT3 versus STAT1 or STAT5, despite their similar SH2 domains, provides a possible basis for the observed STAT3-specificity of compound 1.
