Cell-type specificity of activity levels and plasticity mechanisms suggests that later molecular processes may also differ across populations, including long-term changes underlying memory formation.
Third, in a separate study, some of the same Pseudonocardia strains were used in symbionts-pairing assays with Escovopsis to examine the specificity of activity of antifungal against diverse strains of the parasite (Poulsen et al. in preparation).
The specificity of activity was maintained with a clear difference in the cytolytic activity of targeted and nontargeted (NCAM and mock-transduced cells) being evident.
Although these cell-free data may not always point to a biologically relevant process, the specificity of activity within a complex chemical assay matrix may, nevertheless, provide useful information about the chemical compounds in their interaction with specific protein targets.
The similar information content of the in vitro activities and the structural alerts is furthermore the reason for the almost identical overall agreement, sensitivities, and specificities of activities in vivo with either structural alerts or in vitro activities, with regard to the same subset of compounds (n = 51).
Sds22 in fission yeast has been shown to change the specificity of PP1 activity, increasing PP1 activity toward histone H3 and reducing its activity toward phosphorylase a (Stone et al. 1993).
Considering the specificity of the activities undertaken and the costs of functioning in the territory of the study, there were no private intensive care units.
Histone chaperones and chromatin remodelers bind to and sense PTMs as well, and in many cases the specificity of their activities can be traced to PTM-dependent interactions.
The cleavage state of individual ADAMTS proteinases seems to be of importance, because ancillary domains (particularly the CRD and spacer region) seem to modulate the specificity of their activities, an event that might be of significance in arthritis [ 75].
Our findings establish tRNA maturation as a highly general effector of auxin responses, acting via translational control of PIN proteins, and provoking questions on function and specificity of such activities in the regulation of hormonal signaling (Retzer et al., 2014).
