Sentence examples for specificity of action from inspiring English sources

The tissue specificity of microRNA regulation is known only in some specific cases (e.g. see Table one in [ 58]) and a general methodology for target identification, tissue specificity of action and specific biological role of microRNA in the initiation and progression of most cancers remains an open problem.

Finally, these growth defects accumulate during prenatal and postnatal development in a constrained dose response relationship with the extent of specific killing of GPT neurons, concordant with the purported specificity of action of the genetically targeted ablation (Xie et al., 2002, 2009).

(i) Riboflavin analogues inhibit binding and uptake to nearly the same extent and with similar specificity of action.

Its attractions are temporal and spatial specificity of action, flexibility of waveform parameters and timing, and the perception that its effects are reversible unlike resective surgery.

Many proteases therefore represent therapeutic targets, but the generation of successful small molecule drugs is often limited by the ability to achieve sufficient specificity of action.

In order to validate the results with ISP and to confirm the specificity of action of PTPRS, we used a functionally validated PTPRS siRNA24 to selectively silence the endogenous expression of PTPRS in HCT116, SW620 and KM12L4A CRC cell lines.

Antisense oligonucleotides (ASOs) show immense potential to control the spread of resistant microbes due to its high specificity of action, little risk to human gene expression, and easy design and synthesis to target any possible gene.

Spatial confinement allows the formation of cAMP signaling "hot spots" at discrete subcellular domains in response to specific stimuli, bringing the information in proximity to the relevant effectors and their recipients, thus achieving specificity of action.

What is the extent of the non-specificity of action?

This may be because the sex-specificity of these factors is created during development by means of sex-specific expression, and in our experiments we are forcing expression in each sex, thereby eliminating sex-specificity of action.

The antimalarial drugs differ in their stage specificities of action against malaria parasites.