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In defining the levels of consistency, we used the GO term specificity (P) metric computed based on a term's hierarchical level: (1) P = 1 − Number of Offspring Number of Offspring + Number of Ancestors (Louie et al., 2010) where a GO term is more specific (has a larger specificity metric) if the number of ancestors is greater than the number of descendants.
e, A specificity metric for the binding of each sgRNA variant.
Specificity metric defined as on-target indel rate divided by the sum of all off-target indel rates.
Some researchers may emphasize on the importance of correct predictions that amounts to the sensitivity metric, while others pay more attention to a high number of predictions that amounts to the specificity metric.
Thus, while the specificity metric accurately summarized the increased stage specificity of certain transcripts, such as the telomere-associated lncRNA-TAREs, further comparisons will be necessary to make any global conclusions as to the increased or equivalent specificity of P. falciparum lncRNAs versus mRNAs.
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To overcome this issue, we identified genes that are likely expressed exclusively in a single sex by using a sex-specific metric of tissue specificity: (1) where E i is mean expression of tissue i and Emax is the maximum of the tissue-specific mean expression across all tissues (Yanai et al. 2005).
Surface-based morphometric analyses should complement volumetric findings, providing more specificity in the metric affected (thickness vs. gyrification).
For the comparison, we report positive predictive value instead of specificity as a metric for false positives since the number of true negatives is far larger than the number of false positives, always leading to specificity values greater than 99.9%.
We also calculated specificity of the CPUR metric compared with the CDWR metric as a gold standard (percent of homes classified as unexposed by CDWR metric that were classified as unexposed by CPUR).
When we considered exposure as ≥ 1 lb/mi pesticide use within the buffer, specificity of the CPUR metric, and prevalence of exposure by the CDWR metric was essentially unchanged for each pesticide (data not shown).
As a result, specificity of the CPUR metric was low.
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