Sentence examples for specificity mechanisms from inspiring English sources

The responsibility for the recognition of substrates by protein kinases appears to be distributed among a large number of independent, imperfect specificity mechanisms.

While the sequence variation across the extracellular chemokine receptor domains may provide for ligand specificity, mechanisms of transmembrane domain interaction with 5T4 molecules may be shared with other molecules in the CXC receptor family.

These peptides use novel specificity mechanisms compared to previously designed peptide ligands targeting Mcl-1.

Due to their lack of etiologic specificity, mechanisms or mode of death should not appear on death certificates [ 21- 25].

In this review, a comprehensive summary of the carcinogen-activating role of CYP1A1 is presented, in terms of substrate specificity, mechanisms of carcinogen activation, polymorphisms and extrahepatic expression.

In the case of cnidarian α integrins, ligand specificity cannot be predicted by phylogenetic analysis, suggesting the possibility that specificity mechanisms arose independently in Cnidaria and Bilateria.

This chapter describes the crystal structures of farnesyltransferase (FTase) and their implications on the understanding of substrate specificity, mechanism, and inhibitor design.

(A and B) View of detailed two regions considered as playing crucial role in the specificity mechanism.

Although biased affinity for DNA of high superhelical density would be an attractive mechanism for targeting topoisomerases to where they are needed in the genome, it is not the only possible specificity mechanism.

Interestingly, the effects at the ɛ-cleavage site are also variable for different substrates tested (Km values for APP, Notch, Erb4 and N-Cadherin, Table I), suggesting that some of the clinical mutations affect the substrate specificity mechanism.

SF1 and SF2 helicases can be grouped into families with distinct variations in specificity, mechanism, function, and appended domains (Gorbalenya and Koonin, 1993; Singleton et al., 2007; Fairman-Williams et al., 2010).