Exact(2)
The tethering complexes are the components of the specificity machinery that link all of these factors together either physically, functionally or both.
Notwithstanding this, there is clearly a distinct pattern of conservation between these two components of the specificity machinery, i.e. the poorly conserved tether complexes and the more easily detectable and more highly conserved SM proteins.
Similar(58)
Use specific machinery.
The lichenicidin and haloduracin biosynthetic machinery specificity was investigated in vivo in Escherichia coli.
While auto-editing of the dadar transcript satisfies this prediction, editing in unc-13 is highly variable (see Additional file 5: Figure S4B and C), suggesting that either the unc-13 RNA structure or the specificity of editing machinery has evolved in the species studied, leading to the observed variability.
Both in vivo and in vitro studies indicate low substrate specificity of the modification machinery, which has been explored for re-engineering of the structures of a number of members.
In this model, Importin-α confers cargo specificity to the import machinery [6] and is the necessary intermediary between the cargo and Importin-β.
It has been postulated that palmitoylation of peripheral membrane proteins occurs exclusively in the Golgi apparatus, and that the responsible machinery lacks specificity altogether, rapidly processing any available target protein.
Our findings provide a plausible explanation for the evolution of a relatively large number of molecules to confer specificity on the fusion machinery compared to the relatively small number involved in the budding process.
Experimental data suggest that this proteolytic machinery has specificity to the ASYN species that it can degrade.
Another major set of players in machinery encoding specificity of membrane fusion events are the SM proteins [ 8].
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