To estimate t-value at the given specificity level and the numbers of specific moderate to low avidity TFBSs associated with this t-value, we used the fitting and back-extrapolation method of recovery of the distributions of specific and non-specific BEs.
In addition, the proposed methodology is customizable thanks to the use of two thresholds allowing the user to define the desired specificity level in the display.
Setting the specificity level at 95% resulted in a decrease in sensitivity except for A. baumannii (it reached nearly 100%); it fell below 50% for three pathogens: around 40% for Streptococcus pneumoniae and Enterococcus faecalis and 25% for Enterobacter cloacae.
Our results provide a complete explanation of the DR Raman spectrum, including the D and 2D bands, at the specificity level of a single-chirality nanotube, and will allow for the correct interpretation of the DR spectra of carbon nanotubes in samples containing a distribution of different (n, m) nanotube species.
Using >650 records of experimentally validated steroid hormone response elements, a high sensitivity level of 73% and high specificity level of one prediction per 8.24 kb is reached, allowing this model to be used for further prediction of primary target genes through the analysis of their upstream promoters, for human or other vertebrate genomes of interest.
Moreover, authors also advocated the application of additional discriminatory panels (e.g. non-malignant disease vs. urothelial carcinoma) can increase the specificity level [93].
For ED visits with more than one E-code of the same specificity level, assignment was based on the first-listed E-code cFor each category header, the level of specificity is the mode for that category.
At a specificity level of 99% and 95% the sensitivity level of the different methods was determined for those pairs.
The prediction performance is much better for concept profiles (52% versus 38% for a specificity level of 95%).
The 42 proteins include 7 of the 19 dystrophin-interacting proteins that are known from curated databases (sensitivity of 37% at this very high specificity level).
This list was too long to manually evaluate and we therefore restricted the human curation analysis to the 99.8% specificity level (top 42 proteins, Table S5).
