Sentence examples for specificity issues from inspiring English sources

The X-ray structures of some CDKs especially CDK2 was exploited in the past few years, and several inhibitors have been found, e.g., flavopiridol, indirubicin, roscovitine, etc., but due to the specificity issues of these inhibitors (binding to all CDKs), these were called as pan inhibitors.

The third relates to specificity issues during CNV detection given the coverage of the sum of reported CNV.

Other explanations could involve antibody specificity issues and relative differences in abundance between protein and mRNA in different cells.

We performed additional analyses using non-cancerous disease controls and plasma from cancers other than colorectal to identify potential specificity issues.

It was the maximal concentration we used in our subsequent experiments since its effect on Hh signaling was similar to the one observed after cell differentiation, and to avoid possible specificity issues [24].

Ligand binding assay is associated with a multiplicity of specificity issues (Findlay, 2008).

Hence, our study compares individuals with a long period of real-life training, while accounting for background and training factors (comparing between those with musical experience and bilingual experience) to address the specificity issue.

Only a few studies have tried to address the specificity issue of the NB antibodies.

In the present work, to address this specificity issue, we combine the use of Cdc42 mutants and CRIB protein with Cdc42 binding dead point mutations of N-WASP and Toca-1.

Third, our approach does not address the "specificity" issue with RNAi screens.

Although MOAC seems to be more promising than IMAC, it still faces problems with the specificity issue.