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The TR "germline bias", in which TR/pMHC binding is independent of the nature of the peptide and MHC restriction or TR specificity is based on specific conserved contacts between TR V (variable) domains and MHC proteins that co-evolve [7], has been proposed as one of the solutions.
Increased specificity is based on CMS-ICC exhibiting a fluorescence decay curve that is very distinct from all autofluorescent substances observed in the skin samples (Fig. 1g, j).
SNPlex is based on DNA ligation; therefore, its specificity is based on the characteristics of DNA sequence.
This specificity is based on the low overlapping levels observed for the QTL that influenced the faecal egg counts measured in animals 6 and 13 months of age.
As CRISPR-Cas9 target specificity is based on guide RNAs rather than a modular protein domain, the generation of these 'designer' TFs is faster than the assembly of TALEs (Gaj et al., 2013).
The test's high specificity is based on the reaction to five different antigens, i.e. 110, 98, 95, 60/62, and 48 kDa proteins, which must be recognised by their specific antibodies in order to identify a positive serum [ 2].
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Classical estimates of sensitivity and specificity are based on direct, empirical comparisons of test outcomes for different tests, where an index test is compared to an established "gold-standard" which has an assumed sensitivity and specificity of 100%.
Sensitivity was based on ability of health workers to detect truly positive clinical signs while the specificity was based on the health workers ability to detect truly negative clinical signs.
Estimation of sensitivity and specificity was based on the cutoff value of MTV.
†Sensitivity and specificity are based on authors' preferred cut-off score.
Estimation of specificity was based on the results of nerve conduction tests performed on completely asymptomatic persons randomly selected from a general population.
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