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Exact(55)
It is possible that in TRIMs, extensive sequence reduction has limited similarity to a few key positions for interaction with RT and the primer tRNA (the PPT and PBS) and with INT (the ends of the LTRs), and that most of the specificity is achieved by the specific packaging of the TRIM RNA into the VLP particle (Friedl et al. 2010).
The fact that a specific subset of Fe-S proteins is affected in these newly described diseases suggests that target specificity is achieved through use of specific scaffold proteins that function as intermediates between ISCU and target proteins.
Some specificity is achieved through association with pathway-specific scaffolding proteins that bind GSK-3 and its substrate, such as the β-catenin destruction complex, which sequester GSK-3 from other pathways and lead to highly efficient phosphorylation.
Higher specificity is achieved by the isolation of a specific precursor ion, collision-induced fragmentation and the subsequent detection of the specific product ion after fragmentation.
Our results suggest that genomic binding of STATs is primarily determined by the cell type and further specificity is achieved in part by juxtaposed binding of cell-specific transcription factors.
Indeed, it is unclear how signal specificity is achieved and the relative contribution each receptor has to specific gene expression.
Similar(5)
The P1 primer was the same for the two OCPs and detection and specificity was achieved by two allele-specific Amplifluor P2s carrying either a FAM or a TET fluorophore.
High sensitivity and specificity was achieved with the detection of genomic DNA.
Specificity was achieved through protein plasticity and despite the very high sequence conservation of the enzyme between species.
For the ANN classifier, 94.2% of overall accuracy, 67.7% of sensitivity, and 98.1% of specificity are achieved on the DRIVE database.
A controlled laboratory-reared G. cubensis – F. hepatica system was used for the evaluation of the developed multiplex PCR, and 100% sensitivity and specificity was achieved.
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