Sentence examples for specificity interactions from inspiring English sources
This combinatorial mechanism allows individual low-affinity and specificity interactions to generate a biologically functional, specific, and higher affinity complex despite lacking a defined protein-protein interface.
In good agreement with the high specificity interactions occurring in this seven TAF complex, the TAF8-TAF10 HF pair did not interact with any other HF-containing TAF pair individually or in combination (Table 1, lines 5 8).
A key finding is that a single residue, which in a noncognate context massively destabilizes the complex through frustration, does not participate in specificity directly but rather acts as an organizing center for a multitude of specificity interactions across the interface, many of which are water mediated.
To gauge specificity, interactions were repeated for Leu20Phe FLAG-p7, 15 which conferred resistance to isotopically labeled protein in dye release assays (Fig. 2A).
Because these mutations alter BCRP substrate specificity, interactions between chemotherapeutic agents and wild-type as well as mutant BCRPs have been extensively studied.
The results revealed that cancer-related proteins have smaller, more planar, more charged, and less hydrophobic binding sites than non-cancer proteins, indicating that cancer-related proteins are characterized by low affinity and high specificity interactions.
Engineered antibody paratopes with limited sequence diversity permit assessment of the roles played by different amino acid side chains in creating the high-affinity, high-specificity interactions characteristic of antibodies.
Second, presentation of glycans on a glycoprotein surface increases affinity by 15-to 20-fold, possibly due to low-specificity interactions with the surface of the protein or restriction in the conformation of the glycans.
Histidine coordination and salt bridges by themselves are unlikely to be sufficient for high-specificity interactions.
Translation and translation elongation are also events requiring low-specificity interactions, involving a crowded protein machinery that operates on the entire proteome.
The holoUnaG structure at 1.2 Å revealed a biplanar coordination of bilirubin by reversible π-conjugation, and we used this high-affinity and high-specificity interaction to establish a fluorescence-based human bilirubin assay with promising clinical utility.
