In order to escape obvious logical contradictions and function effectively, a signaling network needs to posses output specificity and input fidelity all its pathways simultaneously.
Theoretical and modeling studies have supported the idea that insulating mechanisms can provide varying degrees of output specificity and input fidelity to interconnected signaling networks [ 22, 25, 38- 42].
The maximum of this expression over all of the parameters occurs when α / β = x 1 Y / x 1 X = C R T, and at this point M F M S = C R T. For scaffolding/compartmentalization (SC), the output specificity and input fidelity readily are calculated: S X = x 1 N | X i n x 1 C | X i n, S Y = x 1 C | Y i n x 1 N | Y i n, F X = x 1 N | X i n x 1 N | Y i n, F Y = x 1 C | Y i n x 1 C | X i n.
Taking this into account, the bias to upper layers may reflect specificity of inputs to area TE from area TEO.
; Input specificity Once induced, LTP at one synapse does not spread to other synapses; rather LTP is input specific.
The use of computer-aided detection certainly has a role in minimising the likelihood of missing some radiologic abnormalities, especially in mammography and lung nodule detection on CT, but carries the negative consequence of the increased sensitivity being accompanied by decreased specificity [43]; radiologist input remains essential to sorting the wheat from the chaff.
Thus only the synapse receiving LTP-inducing stimuli is potentiated, demonstrating LTP's input specificity.
However, the input specificity of LTP may be incomplete at short distances.
NMDA receptor-dependent LTP exhibits several properties, including input specificity, associativity, cooperativity, and persistence.
It thus became necessary to explain how protein synthesis could occur in the cell body without compromising LTP's input specificity.
