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The Endo H specificity includes all high-mannose and hybrid type of glycans from N-linked glycoproteins.
Other evidence for human tumour tissue gene expression specificity includes data presented for brain, breast, colon, endometrium, kidney, liver, lung, ovary, prostate, skin and thyroid cancers [ 32– 32].
In particular, attention must be paid to the lack of power of the interaction test and its interpretation: the logistic model for sensitivity and specificity includes diseased and non-diseased patients and gives results closer to the sensitivity when the proportion of non-diseased patients is high, as is the case here.
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The results indicated that almost all of the COEs showed tissue specificity, including midgut-, heandand integument-, and silk gland-specific expressions.
The enzyme furthermore had a unusual broad substrate specificity, including U, 5-HmU, 5-FU and εC.
Significant parameters with high sensitivity and specificity included spongiosis and exocytosis at the level of SS.
We have extended this approach to the blocking of multiple epitopes simultaneously, which led to the recovery of new antibodies of different specificity, including one new neutralizing activity.
Here, we review the various tools available for target selection in designing engineered nucleases, and for quantifying nuclease activity and specificity, including web-based search tools and experimental methods.
Multiple mechanisms have evolved that contribute to this exquisite specificity, including the structure of the catalytic site, local and distal interactions between the kinase and substrate, the formation of complexes with scaffolding and adaptor proteins that spatially regulate the kinase, systems-level competition between substrates, and error-correction mechanisms.
Carboxylesterases have a broad substrate specificity including compounds with ester, amide, or thioester bonds.
Based on a threshold level of NT-proBNP in relation to age, the sensitivity and specificity (including the 95%% confidence interval) were determined; the sensitivity of finding B-profile on ultrasound was 92.0 %, and the specificity was 91.0 %.
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