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The two biggest issues are that expression of membrane proteins leads to inhibition of cellular growth and metabolism, and native membrane proteins often lack a desired function or specificity for use in engineered processes.
As individual analytes, these proteins evidenced insufficient sensitivity and specificity for use as a biomarker.
Various parameters have been characterized for this purpose, particularly haemodynamic information from invasive right heart catheterization, but none provides adequate sensitivity and specificity for use as independent biomarkers.
These signatures have acceptable sensitivity and specificity for use in our larger study of the impact of the ventilator bundle on risk of VAE.
Detecting medication-related adverse events with adequate specificity for use in a comparative study requires direct observation or case-note review, meaning it would be impossible (or at least ruinously expensive) to conduct an adequately powered study on this basis.
We first validated its spectrum in differential diagnosis, then explored its potential in sensitivity and specificity for use with human serum samples from CCHFV outbreaks in Eastern Europe (Balkan region) and the Middle East.
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Sensitivity and specificity for used phenotypic tests were calculated according to Lee et al. [ 24].
Naturally occurring enzymes have also been engineered to alter their activities and specificities for use in synthetic, environmental and medical applications [7].
The aim of this study was to design a successful strategy to obtain high numbers of Treg with direct alloantigen-specificity for use in transplantation settings.
Sensitivity needs to be increased while maintaining specificity for actual use in an environment with varying antibiotic prescription practices.
An understanding of the structure and function of serpins has suggested that they may provide novel scaffolds for engineering protease inhibitors of desired specificity for therapeutic use.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com